Kousha Zarnegar MD, Presenter: Nothing to Disclose

Kai H Lee PhD, Abstract Co-Author: Nothing to Disclose

Willie Cruz, Abstract Co-Author: Nothing to Disclose

Oscar A Fernandez, Abstract Co-Author: Nothing to Disclose

Suneetha Kothapalli, Abstract Co-Author: Nothing to Disclose

Charles Haddad, Abstract Co-Author: Nothing to Disclose

With the exception of ejection fraction, review of literature reveals little data to define the normal trends of real time change in other left ventricular functional parameters in response to Adenosine infusion during Rb82 PET studies. The purpose of this work is investigation of these normal trends for left ventricular volumes and mass in addition to left ventricular ejection fraction.

Consecutive 110 gated Rb82 rest and 6 minutes adenosine stress myocardial perfusion and function studies, performed using a dedicated PET scanner, are reviewed. Exclusion criteria applied are abnormal perfusion and resting myocardial ejection fraction less than 50%. 72 studies were included in this study. Parameters measured using commercially available software, are rest and stress LVEF, LVEDV, LVESV, SV and LV Mass (LVFP). Statistical analysis is performed to determine the dominant trends of change in functional parameters.

In 72 studies, mean, median, mode and corresponding stress/rest Deltas for LVFP are calculated, which reveal negative Deltas for LVESV (-3, -4 and -7) and positive deltas for LVEF, LVEDV, LVSV and LV mass. The general increase in LVEF, 17%, is due to an increase of 19% in LVEDV (90% of studies), and a decrease of -13% in LVESV (72% of studies) and an increase of 40% in LVSV (96% of the studies). LV mass increases by 20% (94% of the studies). Unparallel change in LVEDV and LVESV is seen in 69% of the studies.

In normal studies, we have found dominant trends of real time change for left ventricular functional parameters measured by Rb82 PET, which are upward for LVEF, LVEDV, SV and LV mass and downward for LVESV. Our findings appear to be in concordance with the results of post adenosine echocardiography and cardiac catheterization studies.

Normal real time functional response to Adenosine in Rb82 PET studies should be defined with regards to dominant patterns for left ventricular volumes and mass in addition to ejection fraction.

Zarnegar, K, Lee, K, Cruz, W, Fernandez, O, Kothapalli, S, Haddad, C, Rubidium 82 PET: Real-time Study of Normal Left Ventricular Functional Response to Adenosine, beyond Ejection Fraction.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4428821.html