Junko Ebi MD, Presenter: Nothing to Disclose

Ami Yukawa MD, Abstract Co-Author: Nothing to Disclose

Masamichi Toshima MD, Abstract Co-Author: Nothing to Disclose

Hisashi Sato MD, Abstract Co-Author: Nothing to Disclose

Fumio Shishido MD, Abstract Co-Author: Nothing to Disclose

Purpose/Objective: To evaluate the effectiveness of high dose fraction radiation therapy (HDRT) for lung tumors as a palliative therapy to maintain patients` quality of life. Materials/Methods: Between February 2002 and March 2005, 20 patients with lung tumors were treated by HDRT without a body frame or a fixation system at Fukushima Medical University Hospital. Of these, 11 patients had primary inoperable lung cancer (Group A), 3 patients had recurrent post operative lung cancer (Group B), and 6 patients had metastatic lung tumor (Group C). The treatment dose was 48-60Gy (mean 50.9Gy) at the center of tumor in 8-10 fractions for 2 weeks. Five or six coplanar x-ray beams of 6 or 10 MV were used. The average tumor volume was 18.2cc (range 2-43). The upper and lower PTV margin was 5-10mm and lateral side was 5mm. CT scans and Xp were performed to evaluate the effectiveness of HDRT. Results: With a mean follow-up period of 17.9 months (range 4-38), a partial response was seen in all patients. Of all 20 patients studied, 16 patients maintained local control. Local progression was observed in 6 patients 5-16 months (mean 7.8) after HDRT. Local control rates were 54.5% (6/11) in GroupA, 100% (3/3) in Group B, and 83.3% (5/6) in Group C. No acute adverse symptoms were observed. Local lung fibrosis was seen in 15 patients around the treated area, but no treatment with steroids was required. Conclusions: HDRT is a safe and effective palliative treatment for lung tumors, and is effective in maintaining quality of life.

Ebi, J, Yukawa, A, Toshima, M, Sato, H, Shishido, F, High Dose Fraction Radiation Therapy for Lung Tumors.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4420624.html