Matthias Schurich MD, Presenter: Nothing to Disclose

Leo Pallwein MD, Abstract Co-Author: Nothing to Disclose

Hannes Steiner, Abstract Co-Author: Nothing to Disclose

Ammar Mallouhi MD, Abstract Co-Author: Nothing to Disclose

Dieter Zur Nedden MD, Abstract Co-Author: Nothing to Disclose

Ferdinand Frauscher MD, Abstract Co-Author: Nothing to Disclose

To determine whether a standardized multiphasic CT imaging grading system, which is based on renal tumor enhancement and morphological patterns, is able to differentiate between histologically low- and high-grade RCC.

In a retrospective study 35 proven and histologically (Fuhrman) graded RCCs were divided in group A (8 lesions with grade 3 and 4) and group B (27 lesions with grade 2 (n=17) and grade 1 (n=10)). The preoperative multiphasic (corticomedullary, venous, and excretory phase) helical CT images were evaluated under standardized criterias by a blinded uroradiologist using following parameters: size, architectural patterns, enhancement characteristics and metastases. Each of the structural and enhancement parameters of tumors was assigned to a specific numeric value, which were summarized to a final score. The mean-scores were compared between group A and B.

In the corticomedullary phase we found a significant (t-test) difference in the mean-score between group A and B. The mean score was 23.9 ±5.5 in group A and 33.9 ±6.5 in group B. In the venous and excretory phase no significant differences could be detected between the scores of low and high malignant lesions.

The multiphasic CT image evaluation system based on morphological and contrast enhancement criterias of renal tumors was able to differentiate between low-grade and high-grade RCCs. This may represent a new prognostic factor and may also have influence in decision of different therapeutic strategies.

Schurich, M, Pallwein, L, Steiner, H, Mallouhi, A, Zur Nedden, D, Frauscher, F, The Role of Multiphasic Helical CT in Estimation of Type of Renal Cell Carcinoma: An Approach Based on Standardized Morphological and Enhancement Parameters.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4419040.html