Markus van Son MD, Presenter: Nothing to Disclose

Klaus Strobel MD, Abstract Co-Author: Nothing to Disclose

Christina Thuerl MD, Abstract Co-Author: Nothing to Disclose

Niklaus G. Schaefer MD, Abstract Co-Author: Nothing to Disclose

Helmut Bammer, Abstract Co-Author: Nothing to Disclose

Steve Ross, Abstract Co-Author: Nothing to Disclose

Thomas Frank Hany MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

Standard 3D reconstructions are based on Fourier rebinning (FORE) to convert 3D data into 2D sinograms followed by 2D iterative reconstruction. We compared standard 2D, standard fast 3D and fast fully 3D PET data acquisition for FDG-PET/CT acquired on a research PET/CT system.

In a total of 14 patients (mean 60 y, 43 - 75; 10 m, 4 f) referred for suspected/known malignancy, FDG PET/CT was performed using a standard dose of FDG on a research PET-CT system with advanced detector technology with improved sensitivity and spatial resolution (GE, Waukesha, WI, USA). After 40 min uptake, a low-dose CT used for attenuation correction from head to thigh was performed followed by 2D (emission 3 min/field) and 3D (emission 1.5 min/field) with both 7 slices overlap to cover the identical anatomical region. PET data was acquired in a randomized fashion, so in 50% of the cases 2D data was acquired first. Standard 2D (s2D) and standard fast 3D (sf3D) PET images were iteratively reconstructed using OSEM and FORE-OSEM, respectively. For fast fully 3D (ff3D) PET, a fully 3D OSEM iterative reconstruction research algorithm was used. Subjective analysis of s2D, sf3D and ff3D images was performed by two observers in a blinded fashion on 5-point scale for sharpness of organs and overall image quality. Further a clinical diagnosis was established. Objective analysis included measurement of SUVmax (with lean body mass) and full-width-half-maximum (FWHM).

The average BMI was 24 (16.5 - 30.7). The overall image quality was subjectively rated 3.75 in s2D, 2.7 in sf3D and 3.75 in ff3D in average. The sharpness of organs was rated 3.5 for s2D, 2.7 for sf3D and 3.5 for ff3D. Objective measurements of SUVmax were highly correlated in all 3 reconstruction methods, but differed significantly in sf3D (minus 31% in average) compared with s2D, whereas in ff3D there was no significant change. FWHM was significantly larger in sf3D (+ 36%) and less in ff3D (-10%) compared to s2D.

3D acquisition together with new reconstruction methods allows to reduce scan time by 50% without loss of clinical information and equal image quality.

H.B.,S.R.: Employee at GE Healthcare Technologies

Standard 3D reconstructions are based on Fourier rebinning (FORE) to convert 3D data into 2D sinograms followed by 2D iterative reconstruction. We compared standard 2D, standard fast 3D and fast fully 3D PET data acquisition for FDG-PET/CT acquired on a research PET/CT system.

In a total of 14 patients (mean 60 y, 43 - 75; 10 m, 4 f) referred for suspected/known malignancy, FDG PET/CT was performed using a standard dose of FDG on a research PET-CT system with advanced detector technology with improved sensitivity and spatial resolution (GE, Waukesha, WI, USA). After 40 min uptake, a low-dose CT used for attenuation correction from head to thigh was performed followed by 2D (emission 3 min/field) and 3D (emission 1.5 min/field) with both 7 slices overlap to cover the identical anatomical region. PET data was acquired in a randomized fashion, so in 50% of the cases 2D data was acquired first. Standard 2D (s2D) and standard fast 3D (sf3D) PET images were iteratively reconstructed using OSEM and FORE-OSEM, respectively. For fast fully 3D (ff3D) PET, a fully 3D OSEM iterative reconstruction research algorithm was used. Subjective analysis of s2D, sf3D and ff3D images was performed by two observers in a blinded fashion on 5-point scale for sharpness of organs and overall image quality. Further a clinical diagnosis was established. Objective analysis included measurement of SUVmax (with lean body mass) and full-width-half-maximum (FWHM).

The average BMI was 24 (16.5 - 30.7). The overall image quality was subjectively rated 3.75 in s2D, 2.7 in sf3D and 3.75 in ff3D in average. The sharpness of organs was rated 3.5 for s2D, 2.7 for sf3D and 3.5 for ff3D. Objective measurements of SUVmax were highly correlated in all 3 reconstruction methods, but differed significantly in sf3D (minus 31% in average) compared with s2D, whereas in ff3D there was no significant change. FWHM was significantly larger in sf3D (+ 36%) and less in ff3D (-10%) compared to s2D.

3D acquisition together with new reconstruction methods allows to reduce scan time by 50% without loss of clinical information and equal image quality.

H.B.,S.R.: Employee at GE Healthcare Technologies

van Son, M, Strobel, K, Thuerl, C, Schaefer, N, Bammer, H, Ross, S, Hany, T, et al, , Comparison of Standard 2D, 3D, and Fully 3D Whole Body FDG-PET/CT Acquisitions on a Research PET/CT System.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4419027.html