Xiao Zhen Li MD, Presenter: Nothing to Disclose

Feng Feng MD, Abstract Co-Author: Nothing to Disclose

Fei Sun, Abstract Co-Author: Nothing to Disclose

Wei Zhou MD, Abstract Co-Author: Nothing to Disclose

Jing Wei MD, Abstract Co-Author: Nothing to Disclose

ZhengYu Jin, Abstract Co-Author: Nothing to Disclose

Severe Acute Respiratory Syndrome (SARS) is a new and deadly clinical syndrome.The objective of this study was to investigate the metabolism in the brain of the post-SARS patients with 1H MRS .

Fifty patients who were caught SARS in 2003 and fifty age-sex matched controls without neurological disorder were studied. The patients group included 16 males and 34 females, with age range from 22 to 68 years (average 40.46 years). The normal control group included 15 males and 35 females, with age range from 24 to 68 (average 41.68 years). All MR image and spectroscopy study were performed on a 3.0T GE scanner. NAA/Cr, Cho/Cr, mI/Cr were acquired PROBE-P sequence with 35ms TE in the anterior cingulate (AC), left frontal periventricular white matter( LFWM), posterior cingulate (PC) and left occipital periventricular white matter (LOWM). Using TE-averaged PRESS sequence detect Glu/Cr and Glx/Cr focusing at AC and LFWM. Statistical analysis was performed by SPSS 13.

All conventional MR imaging appeared normal. In the AC of less then 45-year patients and controls, NAA/Cr were 1.43±0.10 and 1.46±0.10 respectively, Cho/Cr were 0.85±0.08 and 0.87±0.11 respectively, mI/Cr were 0.56±0.08 and 0.63±0.26 respectively, Glu/Cr were 0.25±0.03 and 0.26±0.05 respectivvely, Glx/Cr were 0.35±0.08 and 0.33±0.04 respectively. In the AC of more than 45-year patients and controls, NAA/Cr were 1.37±0.09 and 1.41±0.10 respectively, Cho/Cr were 0.86±0.06 and 0.85±0.04 respectively, mI/Cr were 0.56±0.05 and 0.55±0.07 respectively, Glu/Cr were 0.24±0.05 and 0.25±0.04 respectively, Glx/Cr were 0.31±0.07 and 0.34±0.04 respectively. There was no significant difference between the groups (p＞0.05). In patients, NAA/Cr, Cho/Cr, mI/Cr, Glu/Cr and Glx/Cr were no significantly different from those in the control group in all four regions.

In this study, the metabolism ratios of the brain was no significant change in the post-SARS patients. In conclusion, it might be the human brain would not be infected and/or latent with SARS-CoV.

Li, X, Feng, F, Sun, F, Zhou, W, Wei, J, Jin, Z, 1H MRS Evaluation the Metabolism in Post-SARS with 3.0T.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4416519.html