Li Zhenjia MD, Presenter: Nothing to Disclose

Wang Jing PhD, Abstract Co-Author: Nothing to Disclose

Yu Xianghong BA, Abstract Co-Author: Nothing to Disclose

Wang Ximing PhD, Abstract Co-Author: Nothing to Disclose

Zhang Dianxing PhD, Abstract Co-Author: Nothing to Disclose

Wu Lebin PHD, Abstract Co-Author: Nothing to Disclose

To evaluate the feasibility and effect of CT-Guided Iodine-125 Brachytherapy in treating mediastinal lymph nodes metastasis after artificial pneumothorax.

All 33 cases (twenty-one men and twelve women), aged 37~76 years (average, 61.4 years) of mediastinal lymph nodes metastasis were performed CT-guided interstitial Iodine-125 seeds and low-released 5-Fu implantation after artificial pneumothorax. The radioactivity of Iodine-125 seed is 0.6 ~ 0.8 mci. 5-Fu can enhance the lower initial dosage of Iodine-125 seed. All patients were performed under multi-spiral CT (Philips, Mx8000) with optical navigating system(PinPoint), according to the treatment plan of dosage distributing made by TPS(Treatment Plan System, Hokai Co.). The follow-up examinations, including CT enhancing scan and TM (Tumor Marker), were performed in the 1st, 3rd, 6th month after the therapy respectively. Curative effect was analyzed according to the size of tumor: CR: obvious relief (reduced up to 50%), PR: relief (reduced by 25%-50%); MR: slight relief (reduced by 1%-25%); NR: no effect (the size of tumor did not reduced or increased). Curative efficiency: CR+PR.

Artificial pneumothorax of all cases were successful, and a total of 95 mediastinal puctures were performed. No complications had occurred except that 4 cases have little pleural effusion. The procedures took 95 minites ~ 185 minutes（mean, 145 minutes）. The number of implanted iodine-125 seeds were 5 ~ 24(mean, 14.25). The implanted low-released 5-Fu dosage was 100 ~ 400mg(mean 250mg). Depending on the distributing of Iodine-125 seeds by CT scan, then decided if the patients needed to be implanted again. One month after the therapy: CR 10 cases, PR 14 cases, MR 9 cases, NR 0 cases. 2nd month: R 15 cases, PR 13 cases, MR 5 cases, NR 0 cases. 3rd month: R 14 cases, PR 16 cases, MR 3 cases, NR 0 cases.The curative efficiency rate of tumor size is 72.72%(24/33) one month after the operation, the 3rd and 6th month is 84.84%(28/33) and 90.91% (30/33) respectively.

CT-Guided Iodine-125 seeds Implantation into the mediastinal lesions after artificial pneumothorax is an effective and safe way for mediastinal metastasis.

Zhenjia, L, Jing, W, Xianghong, Y, Ximing, W, Dianxing, Z, Lebin, W, T-guided Iodine-125 Brachytherapy in Treating Mediastinal Lymph Nodes Metastasis after Artificial Pneumothorax.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4414664.html