Zi Lai Pan, Presenter: Nothing to Disclose

Huan Zhang MD, Abstract Co-Author: Nothing to Disclose

Qi Song MD, Abstract Co-Author: Nothing to Disclose

Bei Ding MD, Abstract Co-Author: Nothing to Disclose

Hua Wei Ling MD, Abstract Co-Author: Nothing to Disclose

Kemin Chen MD, PhD, Abstract Co-Author: Nothing to Disclose

In order to establish the new prognostic indicators in gastric adenocarcinoma , the relationship of CT perfusion, histological grade, lymphatic involvement, distal metastasis, TNM staging and microvessel density(MVD) was investigated.

CT perfusion was performed in 31 cases of gastric cancer (20 men, 11 women; mean age 62years, age range 42~79 years)diagnosed by biopsy one week prior to operation. After an oral intake of 1000-1200ml of water and an injection of hypotonic agent, perfusion scan was adopted in multislice CT with 60s of cine duration. Data were analysed by commercial software to calculate tumor blood flow(BF),blood volume(BV), mean pass time(MTT) and permeability surface(PS). MVD was evaluated using immunohistochemical staining of surgical specimens with anti-CD34. All these findings were prospectively analyzed and correlated with the pathological finding. Statistical analysis was performed with t test, spearman correlate and ROC curve in SPSS 13.0.

There is significant difference of PS value not only between patients with and without lymphatic involvement (p=0.038), but also in different histological grade (p=0.04) and TNM staging (p=0.026). ROC curve demonstrated that the accuracy of PS in predicting lymphatic metastasis (area under [Az]=0.78) and histological grading (area under [Az]=0.78) was relatively high. However BF, BV, MTT and MVD of gastric cancer revealed no significant correlation with these clinicopathological findings above (P>0.05).

It can be stated that analysis of CT perfusion imaging in gastric cancer, especially PS value, might be helpful in predicting the prognosis.

Pan, Z, Zhang, H, Song, Q, Ding, B, Ling, H, Chen, K, CT Perfusion in Assessing of Prognosis in Gastric Adenocarcinoma.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4413766.html