Johannes Petersen MD, Presenter: Nothing to Disclose

Martin Cornelius Freund MD, Abstract Co-Author: Nothing to Disclose

Bernhard Glodny MD, Abstract Co-Author: Nothing to Disclose

Volker Dicken PhD, Abstract Co-Author: Nothing to Disclose

Jan-Martin Kuhnigk, Abstract Co-Author: Nothing to Disclose

Werner R. Jaschke MD, Abstract Co-Author: Nothing to Disclose

To evalute a prototype, PC-based software tool for quantitative, emphysema-corrected analysis of pulmonary lobes to predict postoperative pulmonary function after pneumonectomy or lobectomy for bronchial carcinoma from preoperatively acquired MSCT datasets.

Preoperatively all patients underwent contrast-enhanced MSCT with following parameters: 2.5mm slice thickness, 1.25mm (4-slice CT) or 0.625mm (16-slice CT) reconstructed slice thickness, 0.5sec gantry rotation time, standard and lung reconstruction algorithm. Postprocessing was performed by a prototype software tool (MeVisPulmo, MeVis GmbH, Germany) on a commercially available PC (Pentium-IV, 3.0 GHz, 2 GB RAM). The software requires minimal user interaction to confirm lobe segmentation after automatic computation of MSCT datasets. The software corrects for inhomogenous distribution of emphysema, determines volume-density value of planned lung resection and calculates together with preoperatively measured FeV1 the postoperative FeV1. In all patients standard whole body plethysmography including FEV1 values was performed prior to operation and at least 2 months postoperatively. Pneumonectomy (N=5), bilobectomy (N=7) or lobectomy (N=11) was performed in 23 patients for bronchial carcinoma. The predicted FEV1 was compared to postoperatively measured FEV1.

The predicted postoperative FEV1 value ranged from 44% - 96% of the preoperatively measured value. The average discrepancy of predicted versus in-vivo measured FEV1 was 103.5 ml as determined by the Bland-Altman method i.e. the bias between methods. The 95% FEV1 limit agreement ranged from –693 to 486ml with standard deviation of 301.5ml. Spearman rho was 0.84. The 95% confidence interval ranged from 0.64 to 0.93 (p<0.0001).

The PC-based, prototype software tool allows acurate estimation of the postoperative FEV1 from the preoperative acquired MSCT and lung function test. Therefore the new software tool might add useful information for individual decision of operability in patients planned for oncologic lung resection.

To evalute a prototype, PC-based software tool for quantitative, emphysema-corrected analysis of pulmonary lobes to predict postoperative pulmonary function after pneumonectomy or lobectomy for bronchial carcinoma from preoperatively acquired MSCT datasets.

Preoperatively all patients underwent contrast-enhanced MSCT with following parameters: 2.5mm slice thickness, 1.25mm (4-slice CT) or 0.625mm (16-slice CT) reconstructed slice thickness, 0.5sec gantry rotation time, standard and lung reconstruction algorithm. Postprocessing was performed by a prototype software tool (MeVisPulmo, MeVis GmbH, Germany) on a commercially available PC (Pentium-IV, 3.0 GHz, 2 GB RAM). The software requires minimal user interaction to confirm lobe segmentation after automatic computation of MSCT datasets. The software corrects for inhomogenous distribution of emphysema, determines volume-density value of planned lung resection and calculates together with preoperatively measured FeV1 the postoperative FeV1. In all patients standard whole body plethysmography including FEV1 values was performed prior to operation and at least 2 months postoperatively. Pneumonectomy (N=5), bilobectomy (N=7) or lobectomy (N=11) was performed in 23 patients for bronchial carcinoma. The predicted FEV1 was compared to postoperatively measured FEV1.

The predicted postoperative FEV1 value ranged from 44% - 96% of the preoperatively measured value. The average discrepancy of predicted versus in-vivo measured FEV1 was 103.5 ml as determined by the Bland-Altman method i.e. the bias between methods. The 95% FEV1 limit agreement ranged from –693 to 486ml with standard deviation of 301.5ml. Spearman rho was 0.84. The 95% confidence interval ranged from 0.64 to 0.93 (p<0.0001).

The PC-based, prototype software tool allows acurate estimation of the postoperative FEV1 from the preoperative acquired MSCT and lung function test. Therefore the new software tool might add useful information for individual decision of operability in patients planned for oncologic lung resection.

Petersen, J, Freund, M, Glodny, B, Dicken, V, Kuhnigk, J, Jaschke, W, Evaluation of a Prototype, PC-based Software Tool to Predict Postoperative Pulmonary Function after Pneumectomy or Lobectomy for Bronchial Carcinoma from MSCT Datasets.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4412399.html