Natsuko Tsuda MS, Presenter: Nothing to Disclose

Takashi Tsuji BS, Abstract Co-Author: Nothing to Disclose

Naoki Kato PhD, Abstract Co-Author: Nothing to Disclose

Yuko Fukuda MD, Abstract Co-Author: Nothing to Disclose

Kumiko Ando MD,PhD, Abstract Co-Author: Nothing to Disclose

Reiichi Ishikura MD, PhD, Abstract Co-Author: Nothing to Disclose

Norio Nakao MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To investigate possible usefulness of superparamagnetic iron oxide, ferucarbotran, in differentiating bone metastasis from inflammation in implanted rabbit model.

Twelve rabbits with tumor or inflammation in the bone marrow of the right femora were subjected to MR imaging using clinical MRI equipment (n=6). Spin-echo (TR/TE = 3000/40,50,60 or 80 msec) and 2-dimensional T2-weighted spoiled gradient-echo images (TR/TE = 30/20 msec, flip angle 30º) were obtained before and after the intravenous injection of ferucarbotran at a dose of 8 µmol Fe/kg. Signal intensity in the bone marrow of the right femora was measured in each rabbit before and after ferucarbotran injection. As a control, signal intensity in the bone marrow of the left femora was measured in each rabbit. The change in signal intensity of each group was compared statistically. After MR imaging, the femora were removed, and sections were prepared for microscopic examination to confirm lesion extension and tissue characteristic.

Signal intensity in the right femora of the tumor group did not change after injection, although that of the inflammation group and the control group decreased. In the histological findings, tumors were widely spread in the right femora of the tumor group. The infiltration of pseudoeosinocytes was induced in the right femora of the inflammation group.

This study showed that ferucarbotran-enhanced MR imaging provides clear visualization and delineation of tumors in rabbit bone marrow. In addition, ferucarbotran has potential usefulness in the differential diagnosis of bone metastasis and inflammation.

N.T.,T.T.,N.K.,Y.F.,K.A.,R.I.,N.N.: Not disclousure

To investigate possible usefulness of superparamagnetic iron oxide, ferucarbotran, in differentiating bone metastasis from inflammation in implanted rabbit model.

Twelve rabbits with tumor or inflammation in the bone marrow of the right femora were subjected to MR imaging using clinical MRI equipment (n=6). Spin-echo (TR/TE = 3000/40,50,60 or 80 msec) and 2-dimensional T2-weighted spoiled gradient-echo images (TR/TE = 30/20 msec, flip angle 30º) were obtained before and after the intravenous injection of ferucarbotran at a dose of 8 µmol Fe/kg. Signal intensity in the bone marrow of the right femora was measured in each rabbit before and after ferucarbotran injection. As a control, signal intensity in the bone marrow of the left femora was measured in each rabbit. The change in signal intensity of each group was compared statistically. After MR imaging, the femora were removed, and sections were prepared for microscopic examination to confirm lesion extension and tissue characteristic.

Signal intensity in the right femora of the tumor group did not change after injection, although that of the inflammation group and the control group decreased. In the histological findings, tumors were widely spread in the right femora of the tumor group. The infiltration of pseudoeosinocytes was induced in the right femora of the inflammation group.

This study showed that ferucarbotran-enhanced MR imaging provides clear visualization and delineation of tumors in rabbit bone marrow. In addition, ferucarbotran has potential usefulness in the differential diagnosis of bone metastasis and inflammation.

N.T.,T.T.,N.K.,Y.F.,K.A.,R.I.,N.N.: Not disclousure

Tsuda, N, Tsuji, T, Kato, N, Fukuda, Y, Ando, K, Ishikura, R, Nakao, N, et al, , Differential Uptake of Superparamagnetic Iron Oxide between Tumor and Inflammation in Rabbit Bone Marrow.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4411770.html