Teruhito Kido MD, Presenter: Nothing to Disclose

Hiroshi Higashino MD, Abstract Co-Author: Nothing to Disclose

Masao Miyagawa MD,PhD, Abstract Co-Author: Nothing to Disclose

Yoshifumi Sugawara MD, Abstract Co-Author: Nothing to Disclose

Akira Kurata MD, Abstract Co-Author: Nothing to Disclose

Teruhito Mochizuki MD, Abstract Co-Author: Nothing to Disclose

We investigated whether the use of low dose exercise on ATP-loaded myocardial perfusion scitigraphy (MPS) can reduce the side effects of ATP, or improve diagnostic accuracy.

The 583 patients (332 men and 251 women) underwent ATP-loaded MPS. The 224 patients underwent ATP alone (ATP-alone), 201 patients added 15W exercise on ATP-load (15W-EX-ATP) and 158 patients added 25W exercise on ATP-load (25W-EX-ATP). ATP was intravenously infused for 7 minute (0.16mg/kg/min), and 201-Tl, or, 99mTc-MIBI, or 99mTc-tetrofosmin was injected at 3 minutes of infusion. We evaluated chest discomfort, flushing, nausea, sore throat, headache and systolic BP change, diagnositic accuracy, and heart/liver contrast. Sensitivity/specificity of the 3 groups was compared with coronary artery angiography (CAG).

Patients complained chest discomfort, flushing, nausea, sore throat and headache complained in 48%, 31%, 21%, 15%, 5% of ATP-alone, 39%, 20%, 10%, 6%, 1% of 15W-EX-ATP, and 33%, 1%, 14%, 3%, 14% of 25W-EX-ATP, respectively. Heart/liver contrast was improved form 1.13 in ATP-alone to 1.24 in 15W-EX-ATP, and to 1.28 in 25W-EX-ATP, respectively. When compared with CAG, sensitivity/specificity was improved from 62.5%/66.7% in ATP-alone, to 81.8%/71.6% in 15W-EX-ATP, and to 76.2%/84.4% in 25W-EX-ATP, respectively.

Low dose exercise along with ATP-load decreases side effects of ATP and improves diagnostic accuracy of ATP-loaded MPS.

We investigated whether the use of low dose exercise on ATP-loaded myocardial perfusion scitigraphy (MPS) can reduce the side effects of ATP, or improve diagnostic accuracy.

The 583 patients (332 men and 251 women) underwent ATP-loaded MPS. The 224 patients underwent ATP alone (ATP-alone), 201 patients added 15W exercise on ATP-load (15W-EX-ATP) and 158 patients added 25W exercise on ATP-load (25W-EX-ATP). ATP was intravenously infused for 7 minute (0.16mg/kg/min), and 201-Tl, or, 99mTc-MIBI, or 99mTc-tetrofosmin was injected at 3 minutes of infusion. We evaluated chest discomfort, flushing, nausea, sore throat, headache and systolic BP change, diagnositic accuracy, and heart/liver contrast. Sensitivity/specificity of the 3 groups was compared with coronary artery angiography (CAG).

Patients complained chest discomfort, flushing, nausea, sore throat and headache complained in 48%, 31%, 21%, 15%, 5% of ATP-alone, 39%, 20%, 10%, 6%, 1% of 15W-EX-ATP, and 33%, 1%, 14%, 3%, 14% of 25W-EX-ATP, respectively. Heart/liver contrast was improved form 1.13 in ATP-alone to 1.24 in 15W-EX-ATP, and to 1.28 in 25W-EX-ATP, respectively. When compared with CAG, sensitivity/specificity was improved from 62.5%/66.7% in ATP-alone, to 81.8%/71.6% in 15W-EX-ATP, and to 76.2%/84.4% in 25W-EX-ATP, respectively.

Low dose exercise along with ATP-load decreases side effects of ATP and improves diagnostic accuracy of ATP-loaded MPS.

Kido, T, Higashino, H, Miyagawa, M, Sugawara, Y, Kurata, A, Mochizuki, T, Utility of Low Dose Exercise on ATP-loaded Myocardial Perfusion Scintigraphy.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4410653.html