Quido G. de Lussanet MD, Presenter: Nothing to Disclose

Jolanda C. G. van Golde PHD, Abstract Co-Author: Nothing to Disclose

Regina G. H. Beets-Tan MD, PhD, Abstract Co-Author: Nothing to Disclose

Jos M.A. van Engelshoven PhD, Abstract Co-Author: Nothing to Disclose

Walter H Backes PhD, Abstract Co-Author: Nothing to Disclose

Serial MR imaging was performed to monitor collateral vessel growth and muscle blood flow recovery in a rabbit model for peripheral ischemia.

Dynamic contrast-enhanced MR imaging (DCE-MRI) and contrast-enhanced MR angiography (MRA) were performed, with institutional review board approval, in 15 male rabbits, 2 hours (day 0+), 7 days, and 21 days after ligation. DCE-MRI monitored resting muscle blood flow in terms of endothelial transfer coefficient (KPS) in the anterior tibial and soleus muscle, and arterial inflow delay. MRA monitored sub-millimeter collateral vessel growth, for comparison with DCE-MRI.

Anterior tibial muscle KPS reductions at day 0+ (23% (control limb ± SD / ligated limb ± SD, 9±5/2±2), p=0.001) improved by day 7 (81% (7±4/6±2); p=0.0003) and more so by day 21 (85% (10±8/7±6); p=0.0001). Soleus muscle KPS reduced less profoundly at day 0+ (63% (11±12/6±5), p=0.02), and recovered by day 7 (75% (8±2/6±2); n.s., p>0.2) and day 21 (90% (11±8/10±5); p>0.1). Arterial inflow delay normalized from day 0+ (9.2s) to day 7 (2.9s, p=0.01) and more so by day 21 (0.9).

MRI allows non-invasive, serial monitoring of muscle blood flow, and sub-millimeter collateral vessel growth, which bids perspectives for MR monitoring in peripheral vascular disease and drug development.

de Lussanet, Q, van Golde, J, Beets-Tan, R, van Engelshoven, J, Backes, W, MR Monitoring of Collateral Growth and Perfusion Recovery in a Rabbit Femoral Artery Ligation Model.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4410062.html