Abstract Archives of the RSNA, 2005
An Experimental Study on Differentiation of Hyperplastic from Metastatic Lymph Nodes Using a Lymph Node Specific MR Contrast Agent Gadofluorine M
Presented on November 30, 2005
Presented as part of LPL10: Physics (Cellular Imaging, MR Imaging)
Joo Hee Cha MD, Abstract Co-Author: Nothing to Disclose
Woo Kyung Moon MD, Abstract Co-Author: Nothing to Disclose
Young Hwan Koh MD, Presenter: Nothing to Disclose
Jung-Eun Cheon, Abstract Co-Author: Nothing to Disclose
Seung Hong Choi, Abstract Co-Author: Nothing to Disclose
Kyu Ri Son MD, Abstract Co-Author: Nothing to Disclose
Hong Eo MD, Abstract Co-Author: Nothing to Disclose
et al, Abstract Co-Author: Nothing to Disclose
To evaluate the capability of interstitial MR lymphography using Gadofluorine M for the differentiation of hyperplastic and metastatic lymph nodes in rabbits.
This study included 24 rabbits. In 9 animals, hyperplasia of lymph node was induced by injection of egg yolk or feces of rat in the calf muscles. In 15, metastasis of lymph node was induced by implantation of VX2 tumor. We performed T1-, T2-weighted and dynamic SPGR imaging (before, 15, 30, 60 and 90 minutes after injection). Gadofluorine M (5 µmol/ml, total amount 4ml) was injected subcutaneously into the dorsal foot pad. The number, size and location of popliteal and iliac lymph nodes was evaluated. Three readers assessed the state of lymph nodes as hyperplastic or metastatic according to the pattern of enhancement. We also compared the imaging results with histopathological findings.
Histopathologic evaluation of 117 lymph nodes revealed 28 metastatic nodes. Out of 102 lymph nodes larger than 5 mm size, MR enabled detection of 101 lymph nodes (99.1%). The sensitivity, specificity, positive and negative predictive values in the diagnosis of lymph node metastasis were 97.6% (82/84), 98.2% (215/219), 95.3% (82/86), and 99.1% (215/217) (p <0.05).
Interstitial MR lymphography using Gadofluorine M showed excellent results in differentiating hyperplastic from metastatic lymph nodes.
et al, ,
An Experimental Study on Differentiation of Hyperplastic from Metastatic Lymph Nodes Using a Lymph Node Specific MR Contrast Agent Gadofluorine M. Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4408748.html