Yoshiharu Ohno MD, PhD, Presenter: Nothing to Disclose

Munenobu Nogami MD, Abstract Co-Author: Nothing to Disclose

Takanori Higashino MD, Abstract Co-Author: Nothing to Disclose

Sumiaki Matsumoto MD,PhD, Abstract Co-Author: Nothing to Disclose

Hiroto Hatabu MD, PhD, Abstract Co-Author: Nothing to Disclose

Kazuro Sugimura MD, PhD, Abstract Co-Author: Nothing to Disclose

To prospectively demonstrate the utility of krypton-81m ventilation SPECT/CT (Kr-SPECT/CT) for prediction of postoperative lung function in non-small cell lung cancer patients, as compared with technetium-99m labeled macroaggregated albumin perfusion SPECT/CT (Tc-MAA-SPECT/CT) and perfusion planner image (Q scan).

Sixty consecutive patients (30 men, 30 women; mean age 70 years) considered candidates for lung resection underwent multidetector-row CT (MDCT), ventilation and perfusion SPECT, and measurement of forced expiratory volume in 1 second (FEV1) before and after surgery. A SPECT scanner (e-CAM, Siemens Medical Systems) was utilized for obtaining ventilation and perfusion SPECT data. MDCT data was obtained by using a 4 detector-row CT (Somatom Plus 4 Volume Zoom, Siemens Medical Systems) and a 16 detector-row CT (Aquallion, Toshiba Medical Systems). Kr-SPECT/CT and Tc-MAA-SPECT/CT were reconstructed from SPECT and MDCT data by using commercially available fusion software. Prediction of postoperative FEV1s (poFEV1s) by Kr-SPECT/CT, Tc-MAA-SPECT/CT and Q scan were compared with actual poFEV1 at 6 months after surgery, and the limits of agreement between actual and predicted poFEV1 by each method was also determined by Bland-Altman analysis.

Correlations between actual and predicted poFEV1 by using Kr-SPECT/CT (r=0.93, p<0.0001), Tc-MAA-SPECT/CT (r=0.91, p<0.0001) and Q scan (r=0.88, p<0.0001) were excellent. The limits of agreement of Kr-SPECT/CT (-3.3±10.6%) was smaller than that of Tc-MAA-SPECT/CT (-5.4±11.0%) and Q scan (-8.8±11.6%), and small enough for clinical purpose.

Krypton-81m ventilation SPECT/CT can more accurately predict postoperative lung function in non-small cell lung cancer, as compared with technetium-99m labeled macroaggregated albumin perfusion SPECT/CT and perfusion planner image.

To prospectively demonstrate the utility of krypton-81m ventilation SPECT/CT (Kr-SPECT/CT) for prediction of postoperative lung function in non-small cell lung cancer patients, as compared with technetium-99m labeled macroaggregated albumin perfusion SPECT/CT (Tc-MAA-SPECT/CT) and perfusion planner image (Q scan).

Sixty consecutive patients (30 men, 30 women; mean age 70 years) considered candidates for lung resection underwent multidetector-row CT (MDCT), ventilation and perfusion SPECT, and measurement of forced expiratory volume in 1 second (FEV1) before and after surgery. A SPECT scanner (e-CAM, Siemens Medical Systems) was utilized for obtaining ventilation and perfusion SPECT data. MDCT data was obtained by using a 4 detector-row CT (Somatom Plus 4 Volume Zoom, Siemens Medical Systems) and a 16 detector-row CT (Aquallion, Toshiba Medical Systems). Kr-SPECT/CT and Tc-MAA-SPECT/CT were reconstructed from SPECT and MDCT data by using commercially available fusion software. Prediction of postoperative FEV1s (poFEV1s) by Kr-SPECT/CT, Tc-MAA-SPECT/CT and Q scan were compared with actual poFEV1 at 6 months after surgery, and the limits of agreement between actual and predicted poFEV1 by each method was also determined by Bland-Altman analysis.

Correlations between actual and predicted poFEV1 by using Kr-SPECT/CT (r=0.93, p<0.0001), Tc-MAA-SPECT/CT (r=0.91, p<0.0001) and Q scan (r=0.88, p<0.0001) were excellent. The limits of agreement of Kr-SPECT/CT (-3.3±10.6%) was smaller than that of Tc-MAA-SPECT/CT (-5.4±11.0%) and Q scan (-8.8±11.6%), and small enough for clinical purpose.

Krypton-81m ventilation SPECT/CT can more accurately predict postoperative lung function in non-small cell lung cancer, as compared with technetium-99m labeled macroaggregated albumin perfusion SPECT/CT and perfusion planner image.

Ohno, Y, Nogami, M, Higashino, T, Matsumoto, S, Hatabu, H, Sugimura, K, Krypton-81m Ventilation SPECT/CT: Utility for Prediction of Postoperative Lung Function in Non-small Cell Lung Cancer Patients.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4407738.html