Suzanne L. Aquino MD, Presenter: Nothing to Disclose

Elkan F. Halpern PhD, Abstract Co-Author: Nothing to Disclose

Landon B. Kuester, Abstract Co-Author: Nothing to Disclose

Alan Fischman, Abstract Co-Author: Nothing to Disclose

To determine if specific tumor types of non-small cell lung cancer can be identified by variance in FDG-PET standard uptake value (SUV) in combination with characteristics on CT

Staging FDG-PET and CT scans of 89 patients (41 men and 48 women, average age 60.6 + 23 years) with 90 lung cancers were analyzed. All PET and CT scans were obtained 0-30 days of each other. MDCT was at 2.5 mm thickness;IV contrast was given in 74/89. FDG-PET or dual FDG-PET/CT studies were obtained 60 minutes after IV injection of approximately 15 mCi of FDG. Dose, time of injection and the body weight were used to calculate SUV. Tumor mean SUV was calculated at location of maximum FDG uptake. Tumor size, margins, location, lymph nodes, metastases, enhancement/necrosis (latter on contrast studies only) were analyzed on CT. Two-way ANOVA was performed to compare mean SUV measurements between tumor types. Stepwise logistic regression was used to determine if combination of CT and SUV patterns predicted tumor type.

Study group tumors included 40 adenocarcinoma (AC); 13 bronchioloalveolar cell (BAC), 27 squamous cell carcinoma and 10 large cell carcinoma. Average SUV based on tumor type were: all AC 4.2 + 3.3 (range 0.6-11.6); BAC sub-type 1.7 + 1.5 (0.6-5.9); non-BAC AC 5.0 + 3.3 (0.6-11.6); squamous cell 9.3 + 6.5 (1.5 to 22.7); large cell 6.7 + 4.8 (2.9-19.1). Significant differences were found between SUV of BAC/non-BAC AC (p = 0.02); squamous cell/non-BAC AC (p = 0.0002); squamous cell/BAC (p < 0.0001); large cell/BAC (p = 0.0097) and large cell/all AC (p = 0.04); No significant difference was found in SUV between large cell and squamous cell carcinoma or large cell carcinoma and non-BAC AC. None of the CT patterns in combination or independent of SUV predicted tumor type.

Average SUV for non-small cell lung cancers is significantly different between the subtype BAC and all other lung cancer cell types; and between all types of adenocarcinoma and squamous carcinoma. CT features did not improve tumor type distinction.

Aquino, S, Halpern, E, Kuester, L, Fischman, A, FDG-PET and CT Patterns of Non-Small Cell Lung Cancer Based on Tumor Type.  Radiological Society of North America 2005 Scientific Assembly and Annual Meeting, November 27 - December 2, 2005 ,Chicago IL. http://archive.rsna.org/2005/4406474.html