Weijun Zhang, Presenter: Nothing to Disclose

Jiazhong Dai, Abstract Co-Author: Nothing to Disclose

Tianzhen Shen, Abstract Co-Author: Nothing to Disclose

Xingrong Chen MD, Abstract Co-Author: Nothing to Disclose

Kemin Chen, Abstract Co-Author: Nothing to Disclose

Weijun Tang MD, Abstract Co-Author: Nothing to Disclose

To evaluate the value of proton MRS in the differential diagnosis between glioma and radiation necrosis.

53 patients were examined using a combined MR imaging and MR spectroscopy protocol (point-resolved spectroscopy, TR2000 ms/TE 144 ms). The subjects included: 1) 28 patients with 30 lesions of delayed cerebral radiation necrosis after irradiation for nasopharyngeal carcinoma and benign cranial lesions.;2)25 patients with untreated glioma ,15 of them with lower grade glioma(WHO 2 grade) and 10 with higher grade (WHO 3-4 grade). We accessed the distribution of NA/Cr, Cho/Cr, Cho/NA ratios and frequency of mI ,Lac and Lip peak in all above lesions.

In the glioma group, lower WHO grade had lower Cho/Cr, Cho/NA ratios ,and less mI than those in higher WHO grade. Compared with radiation necrosis group, the glioma group reflected lower ratio of NA/Cr and both higher ratios of Cho/Cr and Cho/NA. .After analyzing the distribution of the ratios, we defined the Cho/Cr ratio≥ 1.85 and Cho/NA ratio≥ 2.38 as the standard of glioma, the diagnosis accuracy reached 77.6% and 79.6% respectively.

Both the higher Cho/Cr and Cho/NA ratios suggest more possibility of glioma.

Zhang, W, Dai, J, Shen, T, Chen, X, Chen, K, Tang, W, Clinical Value of 1H MR Spectroscopy for Differentiating Glioma from Delayed Cerebral Radiation Necrosis.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4416213.html