Young-Kon Kim, Presenter: Nothing to Disclose

Hyo-Sung Kwak, Abstract Co-Author: Nothing to Disclose

The purpose of this study was to compare the diagnostic performance of gadobenate dimeglumine-enhanced MR imaging, including dynamic phases and one-hour delayed phase, with superparamagnetic iron oxide (SPIO)-enhanced MR imaging for detection of liver metastases using receiver operating characteristic analysis.

Twenty-three consecutive patients with 59 liver metastases underwent gadobenate dimeglumine-enhanced MR imaging (unenhanced, arterial, portal, equilibrium and one-hour delayed phase) using three-dimensional volumetric interpolated imaging and SPIO-enhanced T2-weighted turbo spin-echo and T2*-weighted gradient echo sequences on a 1.5-T unit. Three observers independently interpreted the three sets of images in random order, independently and without patient identifiers, i.e. gadobenate dimeglumine-enhanced dynamic MRI (set 1), delayed phase imaging (set 2) and SPIO-enhanced MRI (set 3). Diagnostic accuracy was evaluated using the alternative-free response receiver operating characteristic method. Sensitivity and positive predictive value were also evaluated.

The mean accuracy (Az values) and sensitivity of gadobenate dimeglumine-enhanced one-hour delayed phase imaging (0.982, 95.5%) were comparable to those of SPIO-enhanced imaging (0.984, 97.2%). In addition, Az values and sensitivities of both imaging sets were significantly higher than those of gadobenate dimeglumine-enhanced dynamic images (0.826, 77.4%: p < 0.05). There was no significant difference in the positive predictive value among the three image sets although no false-positive findings were found in the gadobenate dimeglumine-enhanced delayed phase imaging.

Gadobenate dimeglumine-enhanced one-hour delayed imaging showed comparable diagnostic performance to SPIO-enhanced imaging for the detection of liver metastases and had a better diagnostic performance than gadobenate dimeglumine-enhanced dynamic images.

Kim, Y, Kwak, H, Detection of Liver Metastases: Gadobenate Dimeglumine-enhanced Three-Dimensional Dynamic Phases and One Hour Delayed Phase MR Imaging versus Superparamagnetic Iron Oxide-enhanced MR Imaging.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4415936.html