Daniel Floery MD, Presenter: Nothing to Disclose

Christopher C Riedl MD, Abstract Co-Author: Nothing to Disclose

Silvia Jaromi MD, Abstract Co-Author: Nothing to Disclose

Wolfgang Matzek MD, Abstract Co-Author: Nothing to Disclose

Michael Herbert Fuchsjaeger MD, Abstract Co-Author: Nothing to Disclose

Thomas Helbich MD, Abstract Co-Author: Nothing to Disclose

To assess the value of Computed Tomography Laser Mammography (CTLM) as an adjunct to Mammography (MG) and Ultrasound (US) in the detection of breast cancer.

In a prospective study, CTLM scans (CTLM scanner Modell 1020 by IMDS, Inc. FL), MG and US of 257 patients were obtained. Histopathological diagnosis (biopsy or surgery) was available in all cases. The CTLM images were read as an adjunct to MG and US.

Of 257 lesions, 135 (52.5%) were benign and 122 (47.5%) malignant including 68 invasive ductal carcinoma (IDC), 21 invasive lobular carcinoma (ILC), 27 ductal carcinoma in situ (DCIS) and six invasive cancers of other types. CTLM achieved a sensitivity of 77.0% (94/122 true positive) and a specifity of 54.1% (73/135 true negative). Positive and negative predictive values were 60.3%, and 72.3% respectively. Sensitivity, specifity, PPV and NPV were 91.0%, 37.8%, 56.9%, and 82.3% for MG and 78.7%, 53.3%, 60.4%, and 73.5% for US. CTLM sensitivity was higher for invasive (77.9 %) vs. non-invasive cancers (74.1%). Sensitivity in breasts with radiologically dense parenchyma (BI-RADS Composition C and D) was 76.2% compared to 78.0% in BI-RADS Composition A and B.

The present results indicate that CTLM may have potential adjunctive value to MG and US in the diagnosis of breast cancer. The radiological density of the breast parenchyma does not lower detection rates significantly.

Floery, D, Riedl, C, Jaromi, S, Matzek, W, Fuchsjaeger, M, Helbich, T, The Role of Computed Tomography Laser Mammography as an Adjunct to Mammography and Ultrasound.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4414398.html