Irfan Akbar Kayani MBBS, Presenter: Nothing to Disclose

Anindo K. Banerjee MBBS, Abstract Co-Author: Nothing to Disclose

Ashley M Groves MBBS, Abstract Co-Author: Nothing to Disclose

Rizwan Syed MBBS, Abstract Co-Author: Nothing to Disclose

Jamshed Bomanji MBBS, Abstract Co-Author: Nothing to Disclose

Peter Joseph Ell MBBS, Abstract Co-Author: Nothing to Disclose

Penny Shaw MBBS, Abstract Co-Author: Nothing to Disclose

Jeremy George MBBS, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

A prospective study to identify the ability of 18F-FDG PET-CT (PET-CT) to stage preinvasive lung lesions identified following fluorescence bronchoscopy.

Patients identified with preinvasive lung lesions on fluorescence bronchoscopy and histology underwent staging PET-CT scans as part of the diagnostic workup. Positive scans were classified as localized or disseminated disease.

Fourteen patients with preinvasive bronchial lesions had a PET-CT scan. Nine of the fourteen had a history of previous invasive lung carcinoma treated with surgery and/or radiotherapy or of coexistent invasive squamous lung carcinoma. Nine of fourteen patients had FDG avid lesions at sites corresponding to bronchoscopic abnormality. Two of nine patients with positive scans also had FDG avid disease within mediastinal (two patients) and hilar nodes (one patient) and a subpleural lung mass lesion (one patient). In five of fourteen patients the bronchoscopic site was not FDG avid. These five negative scans included two of two patients with squamous metaplasia, the only patient with dysplasia and two of ten patients with carcinoma in situ (CIS).

Our interim data analysis suggests that PET-CT can detect CIS and localised microinvasive disease in addition to incidental cancers at remote sites. PET-CT appears less sensitive in the detection of low grade dysplasia. Follow up data and ongoing recruitment of patients will allow insight into the prognostic significance of PET-CT.

Kayani, I, Banerjee, A, Groves, A, Syed, R, Bomanji, J, Ell, P, Shaw, P, George, J, et al, , The Role of 18F-FDG PET-CT in the Localising of Preinvasive Bronchial Epithelial Lesions.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4414019.html