Beatriz E. Amendola MD, Presenter: Nothing to Disclose

Marco A. Amendola MD, Abstract Co-Author: Nothing to Disclose

Christina Lopez-Peñalver MD, Abstract Co-Author: Nothing to Disclose

Chunsong Luo PhD, Abstract Co-Author: Nothing to Disclose

Accelerated Partial Breast Irradiation (APBI) in selected patients with early breast cancer reduces the overall time of treatment to one week compared to the conventional six week course of radiation therapy in women pursuing breast conservation treatment. Our purpose is to present the results of APBI using the MammoSite system in patients treated in a single institution in a prospective study.

Between June 2002 and March 2004, 22 patients with early breast cancer underwent placement of the MammoSite balloon delivery system for consideration of High Dose Rate brachytherapy. Three of the 22 MammoSite devices were removed: 2 due to positive margins and one because of poor implant dosimetry. Doses ranged from 30.6 Gy to 34 Gy in 10 fractions of 3.4 Gy each treated twice daily (BID). All patients were treated with the VariSource 200 Unit and planned with BrachyVision 2000 software. All patients underwent initial CT planning with 3D reconstruction and then had ultrasound for daily confirmatory setup. All patients treated had lumpectomy with negative margins, tumors less than 3 cm in dimension and negative metastatic work-up, including whole body PET scans. All patients received adjuvant systemic therapy post MammoSite.

None of the 19 patients has had local recurrence. Two patients developed infection at the balloon site: one had received chemotherapy for a contralateral breast cancer 2 years prior to MammoSite HDR, and the other patient received chemotherapy within a week of treatment. In a scale of 1 to 10, pain level ranged from 0 to 2 in all patients. Cosmesis was excellent in 17 of 19 patients (89%). Patient satisfaction was 100%.

In our initial experience, APBI with the MammoSite system for the management of selected patients with early breast cancer has excellent initial local control, low incidence of complications and high patients’ acceptance with excellent cosmesis. In addition, its shortened treatment time makes it a highly attractive treatment modality. Further follow up is needed to evaluate its long term results.

Amendola, B, Amendola, M, Lopez-Peñalver, C, Luo, C, Accelerated Partial Breast Irradiation for Early Cancer Using the Mammosite System.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4412588.html