Xiao Ying Wang, Presenter: Nothing to Disclose

Fei Yu Li, Abstract Co-Author: Nothing to Disclose

Jian ping Ding, Abstract Co-Author: Nothing to Disclose

Xue xiang Jiang, Abstract Co-Author: Nothing to Disclose

Using MRS to investigate the effect of post-biopsy hemorrhage on the normal prostate peripheral zone and prostate cancer foci.

21 patients with biopsy proved prostate cancer were enrolled in this study. They were examined by MRS 10days, 20 days and 30 days after the biopsy sequentially. The prostate was divided into 6 regions (left/right bottom, middle and tip). The locations of the prostate cancer foci were marked as one or more of the sextants according to the pathological results obtained by ultrasound guided systemic biopsy. The valid number of (Cho+Cre) and Cit peaks (SNR>5) was counted for qualitative analysis. The CC/C value of each region with valid metabolites was measured for quantitative analysis.

1)In 10 days after biopsy, all sextants without tumor (75)revealed hemorrhage in T1WI and showed no remarkable metabolic peaks(SNR<5). In 20 days after biopsy, 43%(32/75) of the above sextants demonstrated (Cho+Cre) and Cit peaks, and the average CC/C ratio was 0.81±0.23. In 30 days after biopsy, 89%(67/75) sextants displayed distinct (Cho+Cre) and Cit peak, and the CC/C ratio was 0.64±0.17. 2) In 10 days after biopsy, 14% (7/51)sextants with tumor revealed hemorrhage in T1WI, and 57%(4/7) of them showed no remarkable metabolic peaks(SNR<5) and the other 43%(3/7) of them showed valid (Cho+Cre) peak without any detectable Cit peak. In 20 days after biopsy, 59%(30/51) of the tumor sextants demonstrated (Cho+Cre) and Cit peaks, and the average CC/C ratio was 2.23±0.43. The other 41%(21/51) tumor sextants demonstrated (Cho+Cre) peak only. In 30 days after biopsy, 75%(38/51) tumor sextants displayed distinct (Cho+Cre) and Cit peak, and the CC/C ratio was 2.19±0.46. The other 25%(13/51) tumor sextants demonstrated (Cho+Cre) peak only.

The post-biopsy hemorrhage can affect the MRS of the normal and cancerous region of the prostate. The Citrate peak is affected more obviously than the (Cho+Cre) peak.

Wang, X, Li, F, Ding, J, Jiang, X, The Effect of Post-Biopsy Hemorrhage on the Normal Prostate Peripheral Zone and the Prostate Cancer Foci: Evaluated by MRS.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4409293.html