Ahmed A Abdel Razek MD, Presenter: Nothing to Disclose

Ahmed Abdalla, Abstract Co-Author: Nothing to Disclose

Mohammed Ezz, Abstract Co-Author: Nothing to Disclose

Nahid Abdel Gabir, Abstract Co-Author: Nothing to Disclose

Marvat Shafik, Abstract Co-Author: Nothing to Disclose

Abeer Fathy, Abstract Co-Author: Nothing to Disclose

Ashef Abdel Rahman, Abstract Co-Author: Nothing to Disclose

Magdy El-Rakhawy, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To assess apparent diffusion coefficient (ADC) value as a new quantitative parameter to detect bone marrow infiltration in pediatric patients with Gaucher disease.

Nineteen patients (12M,7F aged 2-10ys: mean 4.5ys) with Gaucher disease underwent diffusion weighted MR imaging & quantitative chemical shift imaging (QCSI) of the lumbar spine. Ten of these patients underwent follow up MR after enzyme replacement therapy (ERT). A total of 19 aged matched volunteers underwent the same MR study. Diffusion MR weighted imaging was done on 1.5 tesla unit (Symphony, Siemens) using a single shot spin echo type of echo planar imaging. The parameters used were TR/TE: 4200/38 msec, B value = 0, 500 & 1000 sec/mm2. The ADC map was reconstructed and ADC value of the lumbar vertebral bodies was calculated.

The mean ADC value of cellular bone marrow in volunteers was 0.68±0.13 X 10-3 mm2/sec. The mean ADC value of marrow infiltration in Gaucher patients was 0.36±0.11 X 10-3 mm2/sec. After enzyme replacement therapy, the mean ADC value gradually increased and reached to 0.53±0.18 X 10-3 mm2/sec. The was statistically difference in ADC value between cellular marrow in normal volunteers & marrow infiltration in Gaucher patients (P<0.001) and in Gaucher patients before and after enzyme replacement therapy (P<0.002). The mean ADC values was correlated with QCSI results.

We concluded that apparent diffusion coefficient value is a new promising quantitative imaging parameter for detection of bone marrow infiltration in pediatric patients with Gaucher disease and for assessing therapeutic response to enzyme replacement therapy.

Abdel Razek, A, Abdalla, A, Ezz, M, Abdel Gabir, N, Shafik, M, Fathy, A, Abdel Rahman, A, El-Rakhawy, M, et al, , Bone Marrow Infiltration in Pediatric Patients with Gaucher Disease: Quantitative ADC Value Assessment.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4407513.html