Christine P. Chao MD, Presenter: Nothing to Disclose

Amy Louise Kotsenas MD, Abstract Co-Author: Nothing to Disclose

Daniel F. Broderick MD, Abstract Co-Author: Nothing to Disclose

1)Identify the CT and MR imaging characteristics of cerebral amyloid angiopathy (CAA).2)Describe the clinical presentations that correlate with specific imaging findings.3)Discuss the importance of early radiographic detection for the proper management of CAA.

Cerebral amyloid angiopathy (CAA) is an under-recognized but important cause of cerebrovascular disorders predominately affecting elderly patients. CAA results from deposition of ß-amyloid protein in cortical and leptomeningeal vessels. This is responsible for the wide spectrum of clinical symptoms and neuroimaging findings. Many cases of CAA are asymptomatic. When symptomatic, patients can present with transient neurologic events, progressive cognitive decline and potentially devastating intracranial hemorrhage. CT is the imaging study of choice to evaluate acute cortical hemorrhage which may be accompanied by subarachnoid, subdural or intraventricular hemorrhage. MRI is best suited to identify small cortical hemorrhages and ischemic sequela of this disease, to exclude other diagnoses, and to assess disease progression. As biopsy to confirm diagnosis is often contraindicated, accurate recognition of imaging findings is crucial in guiding clinical decision making in patients with CAA.

Chao, C, Kotsenas, A, Broderick, D, Cerebral Amyoloid Angiopathy: CT and MR Imaging Findings.  Radiological Society of North America 2004 Scientific Assembly and Annual Meeting, November 28 - December 3, 2004 ,Chicago IL. http://archive.rsna.org/2004/4404018.html