Abstract:
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Purpose: The purpose of this study is to investigate whether there is an increased incidence of Dipyridamole (Persantine)-induced side effects based on either gender or Body Mass Index (BMI).This can assist the supervising Physician to predict which individual may have a higher risk of side effects. The prevalence of side effects in our institution was also compared to previously published data.
Methods and Materials: 100 patients (Mean age 57 years old; 46 female,54 male) were randomly selected for this prospective study . BMI was calculated by each patient's height and weight(BMI =Weight in Pounds / (Height in inches) x (Height in inches)x 703 ) The BMI was ranked as Low ( 12-18.4), Normal (18.5-25),or High (25.1-45). The standard protocol of Dipyridamole 0.142 mg/kg/min IV was infused over 4 minutes for the stress portion of the cardiac SPECT study.During and post-infusion,patients were asked to describe any side effects.Continous ECG and BP monitoring were performed until 20 minutes postinjection. Chest pain and headache were graded as mild,moderate and severe.
Results: 62/100 patients experienced either one or multiple side effects.A total of 18 various side effects were observed.The most common were: headache (28%), chest pain (21%), flushing (18%).No major side effects such as myocardial infarction or bronchospasm was observed. 53% of the patients with a High BMI complained of side side effects; 40% of with normal BMI, and 7% with low BMI.This was statistical significant. The subgroup with the highest incidence were females with a high BMI( 62%). Overall,74% of the female patients experienced side effects vs. 52% for male patients.This was also statistically significant. Comparing the incidence of various side effects to published data,our study demonstrated a higher incidence of headache and flushing and dyspnea;a lower incidence of dizziness,and ECG changes.Chest pain and nausea were not statistically significant
Conclusion: Body Mass Index measurements predicts the probablity of Dipyridamole induced side effects for Cardiac SPECT perfusion imaging.Patients with higher Body Mass Index values have a statistically significant incidence.There was a significant difference in side effects comparing female and male patients.The subgroup with the highest rate of side effects were females with high Body Mass index.This data can assist the supervising Physician to predict the probablity of Dipyradimole induced side effects.
Hershkop MD, M,
Predicting The Incidence of Dipyridamole(Persantine) Stress Cardiac SPECT Induced Side Effects Using Body Mass Index and Gender. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3107733.html
