Abstract:
HTML
Purpose: To assess feasibility of 3D volume follow-up in ACI patients. To evaluate one year volume and thickness change in a pilot group of patients.
Methods and Materials: 20 patients (21-54y) underwent ACI for either osteoarthritic or osteochondral articular cartilage loss. All patients were imaged prior to surgery and at one year with a FS 3D FLASH (50/11/30; 0.6x0.6x1.5mm3) MR sequence in the sagittal plane. Calculation of segmentation reproducibility (COV%) was performed in 4 patients from 4 repeat segmentations per patient. After semi-automatic segmentation (consensus of two readers) 3D reconstruction of the femoral cartilage plates was performed and cartilage volume, mean thickness and the size of the cartilage bone interface were calculat
Results: Reproducibility (COV) was 3.6%. In 3 of 21 patients severe susceptibility artifacts prevented segmentation. The pre-graft volume ranged from 15571 to 22365mm3 (mean 18192), the post graft volume was 15812 to 23044 (mean 18552), the difference was +11.52% to -11.57% (mean +2.13%). The area of the cartilage bone interface varied between pre and post surgery by -3.29% to +4.92%. Defect volume 0.49+/- 0.31 mm3.
Conclusion: Despite the presence of some postoperative susceptibility artefacts careful computer rendering can produce satisfactory volume measurements. MRI based volumetric assessment of femoral cartilage appear applicable to ACI. Cartilage volume of the femoral condyles at one year is not significantly altered by the ACI graft except in the presence of considerable graft overgrowth or graft failure. The results give a baseline for further long term (3years) follow-up. 3D reconstruction may facilitate detection and estimation of regional analysis as in OA not only one single defect may be present and therefore volume increase by ongoing graft tissue may be overruled by cartilage loss in other joint locations
Questions about this event email: christian.glaser@ikra.med.uni-muenchen.de
Glaser MD, C,
Quantitative 3D MR Follow-up of Cartilage Volume and Thickness in Autologous Chondrocyte Implantation (ACI) in the Knee. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3107543.html
