Abstract:
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Purpose: To establish a normal range of end-systolic and end-diastolic left ventricular volumes with rest and after stress and to develop a clinical index of abnormality of gated left ventricular cardiac volumes.
Methods and Materials: Previous published work in our center has established a correlation of gated cardiac SPECT ventricular volumes with echocardiography. In this study we measured gated volumes in all patients undergoing stress perfusion cardiac scans for suspected coronary disease using a double headed gamma camera using the MULTIDIM analysis package. Patients were stratified as normal (n=65) if they had a normal ejection fraction (>60%) and a normal myocardial perfusion index using the MYOQUANT calculation package. Abnormal patients had evidence of significant non-reversible defects and a MYOQUANT score >5(n=46) Stress imaging was undertaken 1.5 hours after stress when the ECG, pulse rate and blood pressure had normalized.
Results: 65 patients (26 male, 40 female, average age 60.1 yrs) had a normal ejection fraction and a normal MYOQUANT score. The average end-diastolic volume at rest was 113.05+/-32.13 mls. Average end-diastolic volume after stress was 113.32+/-30.41. Stress and rest examinations were taken 7 days apart. Average end-systolic volumes were 35.9+/-12.42 mls.(stress) and 33.49+/-13.31(rest). The abnormal group had an average end-diastolic volume of 257.37+/-70.034 mls. (after stress) and 259.75+/-82.01mls. (at rest)Average end systolic volumes were 142.7+/-77.12 mls. (after stress) and 138+/-62.27 mls. (at rest). Correlation of stress and rest volumes was greater than r=. 94 in all studies
Conclusion: Left ventricular volumes can be measured with significant reproducibility by gated SPECT imaging and may be a significant indicator of severity of disease in the assessment of myocardial perfusion imaging.
Questions about this event email: m.rees@bris.ac.uk
Rees MD, M,
Calculation and Relevance of Left Ventricular Volumes Measured by Gated Cardiac SPECT Imaging. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3107438.html