Abstract:
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Purpose: To compare structure measures obtained from high resolution magnetic resonance (HR-MR) images of the distal radius, bone mineral density (BMD) of the forearm using dual-energy-X-ray-absorptiometry (DXA) and the spine using quantitative computed tomography (QCT) in predicting failure load of the forearm in a cadaver study
Methods and Materials: Coronal and axial HR-MR images of the right distal radius were obtained in 74 human cadavers (44 females: 30 males; mean age 76.6 +/- 10.6 years) at 1.5T using 3D-gradient echo sequences (slice thickness: 0.5 mm, in plane spatial resolution: 0.195 x 0.195 and 0.156 x 0.156 mm2). In these images structure analysis was performed using parameters analogous to standard histomorphometry. In the same specimens BMD measurements were obtained using DXA. QCT was performed in the tenth thoracic and the fourth lumbar vertebrae. Then the forearm specimens were subjected to destructive biomechanical testing, simulating a fall onto the outstretched forearm and failure load was determined.
Results: Structure measures of the distal radius and failure load were significantly correlated (p<0.01), correlation coefficients of r up to 0.71 were obtained. The best correlation coefficients were obtained for the axial MR images with the highest in plane spatial resolution. While trabecular BMD of the spine showed only moderate correlations with the failure loads (r up to 0.52), areal BMD of the distal radius was highly correlated with the failure load (r=0.79). Using multivariate regression analysis and combining structure and BMD of the forearm provided the highest correlation of r up to 0.85 (p<0.01).
Conclusion: In this in vitro study BMD of the distal radius was best suited to predict failure load of the forearm in a complex fall simulation. However, combining structure measures and BMD provided the best results. BMD of the spine was only moderately correlated with failure load of the forearm.
Questions about this event email: tmlink@roe.med.tu-muenchen.de
Link MD, T,
High Resolution MRI of the Distal Radius for Trabecular Bone Structure Analysis: Comparison with BMD in the Prediction of Failure Load of the Forearm. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3104067.html
