Patients were eligible if they had clinical and imaging diagnosis of Osteoid Osteoma. Lesions located in vertebral body were excluded; recurrences after RFA or surgery were included. Patients received focal therapy using MRgFUS (InSightec), delivered toward the nidus. Primary endpoints were pain relief assessed using questionnaires on Visual Analog Pain Score (VAS) and daily intake of Non-steroidal drugs (NSAIDs); secondary endpoints were need for further intervention and bone changes analyzed at imaging (CT and dynamic CE-MRI; Gd-BOPTA, Bracco). Patient’s follow-up, including clinical and imaging examinations, was established at 1 and 12 months

Our study included 44 patients (14 female and 30 males; mean age 61,4 ± 9,5) suffering from metastatic bone disease. All patients were considered non responders to conventional therapies (radiation, analgesic drugs) and were preliminary analyzed by contrast-enhanced MR imaging and pain scale assessment (Quality of Life Questionnaire-BM22 and VAS scale). We treated 52 non-vertebral skeletal metastases with MRgFUS (ExAblate 2100, InSightec). Follow-up evaluation comprehended MR scan and pain scale scoring at 3 and 6 months after treatment.

We retrospectively reviewed all cases of RPOC performed in our hospital in patients suffering from osteolytic metastases with or to prevent pathological fracture. An impending pathological fracture was defined by a Mirels' score > 8.

After institutional review board the patients were not candidates for surgery due to poor performans status, refusal or on-going chemotherapy. RPOC was performed with cannulated screws under computed tomography and scopic guidance with a CT-Navigation device.We retrospectively analyzed occurrence of post-procedural fractures, reduction in pain, technical feasibility, duration in the operating room, early complications and duration of hospitalization.

19 patients (13 females, mean age 72±10 y) underwent elastoplasty between 2010 and 2016. 14 patients had osteoporotic fractures, 2 patients traumatic fractures, 1 patient a painful myeloma localization, and 1 patient a painful vertebral angioma. 15 patients were using a brace and all were consuming drugs for pain relief. A total of 33 vertebrae were treated (range L1-T6). Patients were treated under local anesthesia and fluoroscopic guidance, using transpedicular approach and 2-6 ml of silicone based elastomeric polymer material (VK100) was injected by an interventional radiologist with more than 20 years’ experience in vertebroplasty.  Chest x-ray was performed after the procedure in order to detect pulmonary embolism. Immediate and late complications, if any, were recorded, and VAS and Oswestry before and after the procedure evaluated. 

Institutional review board approval and informed consent were obtained for this study. Sixty-three consecutive adult patients (35 women, 28 men; mean age +/- standard deviation: 69 years +/- 14) with tumoral spinal fractures that compromised the posterior vertebral column with epidural involvement were prospectively treated by means of percutaneous vertebroplasty with CT and fluoroscopy guidance. Only local anesthesia was used during these procedures. Postoperative outcome was assessed using the Kostuik index.

Patients with OVCFs who underwent their first PVP in our department between January 2007 and December 2013 were included in this study. Univariate and multivariate analysis were used to predict the independent risk factors. The Nomogram was then created based on the identified independent risk factors.

Twenty patients (7 men and 13 women, median age 52 years) with 24 vertebral metastases (7 NSCLC, 7 multiple myeloma, 6 breast carcinoma) underwent CT–guided PSFPC. The procedure was performed in a single vertebra in 16 patients and in two vertebrae in 4 patients. The vertebral approach was unilateral with a single screw in thirteen patients and bilateral with two screws in the remaining 7. We analyzed the feasibility and complications of the procedure, the decrease in pain using a visual analogue scale (VAS) and the functional outcome assessed according to the evolution of their walking ability.

We retrospectively reviewed 247 consecutive percutaneous spinal biopsies. Size (< 2 cm and ≥ 2 cm), location (C-, T-, L-spine, and sacrum), and CT density (osteoblastic, osteolytic, mixed, and isodense) of the lesion, guiding modality (CT and fluoroscopy), years of biopsy attending experience (< 2 years and ≥ 2 years), number of approach (one and ≥ 2), pathologic report of the biopsy, and final diagnosis of the lesion were recorded. A biopsy was considered as diagnostic if it provided a confident pathologic result or non-diagnostic if the pathology could not suggest a specific diagnosis. All variables were compared using Pearson’s chi square test or Fisher’s exact test.

Following Institutional Animal Care and Use Committe approval, 3 juvenile female miniature pigs underwent a 2-arm study using the animals as their own control. Pigs #1 and #2 underwent CT-guided periarticular bone ablations (pig#1-Cryo; pig#2-RFA) at 4 different sites each, and all limbs (including 1 control site) were removed from both pigs immediately following the procedures. Pig #3 underwent periarticular bone Cryo or RFA at 3 different sites each, and all limbs (including 1 control site) were removed 7 weeks following the procedure. For all ablations, an 11-gauge coaxial introducer was percutaneously advanced into the target epiphyseal site followed by placement of single RFA or Cryo probe 1cm from the articular surface under general anesthesia. RFA was performed for a total of 6 minutes at a target temperature of 90 degrees Celsius using 17G cooled-tip electrodes. Cryo was performed using 17G probes for two 10-5-minute freeze-thaw cycles. All bone and articular cartilage specimens were examined histologically with H&E staining.