RSNA 2016

Abstract Archives of the RSNA, 2016


SSA14-03

Defining Sarcopenia with MRI - Establishing Threshold Values within a Large-Scale Population Study

Sunday, Nov. 27 11:05AM - 11:15AM Room: S406A



FDA Discussions may include off-label uses.

Anette Karlsson, Linkoping, Sweden (Abstract Co-Author) Stockholder, AMRA AB
Jennifer Linge, Linkoping, Sweden (Abstract Co-Author) Employee, AMRA AB
Janne West, MSc, PhD, Linkoping, Sweden (Abstract Co-Author) Employee, AMRA AB; Stockholder, AMRA AB
Jimmy D. Bell, PhD, London, United Kingdom (Abstract Co-Author) Nothing to Disclose
Magnus Borga, PhD, Linkoping, Sweden (Abstract Co-Author) Stockholder, AMRA AB
Olof Dahlqvist Leinhard, PhD, Linkoping, Sweden (Presenter) Stockholder, AMRA AB; Employee, AMRA AB
PURPOSE

To identify gender specific threshold values for sarcopenia detection for lean thigh muscle tissue volume quantified using MRI.

METHOD AND MATERIALS

Current gender-specific thresholds for sarcopenia detection are based on quantification on appendicular lean tissue normalized with height^2 using DXA (7.26 kg/m^2 for men and 5.45 kg/m^2 for women). In this study 3514 subjects (1548 males and 1966 females) in the imaging subcohort of UK Biobank with paired DXA and MRI scans were included. The age range was 45 to 78 years. The total lean thigh volume normalized with height^2 (TTVi) was determined with a 6 minutes neck to knee 2-point Dixon MRI protocol using a 1.5T MR-scanner (Siemens, Germany) followed by analysis with AMRA® Profiler (AMRA, Sweden). The appendicular lean tissue mass normalized with height^2 (ALTMi) was assessed using DXA (GE-Lunar iDXA). Subjects with ALTMi lower than the gender specific threshold were categorized as sarcopenic. Gender specific threshold values were determined for detection of sarcopenic subjects based on TTVi optimizing sensitivity and specificity. Area under receiver operator curve (AUROC) was calculated as well as the linear correlation between TTVi and ALTMi.

RESULTS

A threshold value of TTVi = 3.64 l/m^2 provided a sensitivity and specificity of 0.88 for sarcopenia detection in males. The AUROC was 0.96. Similarly, a TTVi < 2.76 l/m^2 identified sarcopenic female subjects with a sensitivity and specificity of 0.89. The corresponding AUROC was 0.96. The linear correlation between TTVi and ALTMi was 0.93 (99%CI: 0.93-0.94).

CONCLUSION

MRI-based quantification of total lean thigh volume normalized with height^2 could be used to categorize sarcopenia in the study group. Threshold values are suggested.

CLINICAL RELEVANCE/APPLICATION

The study suggests that sarcopenia can be diagnosed using a rapid MRI scan with high sensitivity and specificity.