Angiosarcoma of the breast is a rare malignancy that develops from endothelial cells lining the blood vessels in the breast. It can manifest as a primary lesion or a secondary lesion that develops after breast cancer treatment. The objective is to review the clinical presentation, pathophysiology, and imaging findings of primary and secondary angiosarcoma of the breast. Challenges in diagnosing angiosarcoma and imaging mimics of the disease will also be reviewed.
TABLE OF CONTENTS/OUTLINEPrimary and secondary angiosarcoma of the breast introduction Clinical presentation Epidemiology Risk factors Pathophysiology Outcomes Anatomy of the breast Diagnostic work-upReview of imaging findings Mammogram Ultrasound MRI CT PET-CTChallenges in diagnosing angiosarcoma of the breastMimics of angiosarcoma Post surgical/radiation skin thickening Dermal metastasisInteresting case examples Primary angiosarcoma in breast with implant Recurrent primary angiosarcoma after misdiagnosis as benign lobular hemangioma Secondary angiosarcoma in mastectomy scar Recurrent secondary angiosarcoma after local excision without preop imaging to evaluate extent of diseaseFuture directions and summary