Abstract Archives of the RSNA, 2014
Han Lv, Presenter: Nothing to Disclose
Zhenchang Wang MD, PhD, Abstract Co-Author: Nothing to Disclose
Fei Yan, Abstract Co-Author: Nothing to Disclose
Zhaohui Liu MD, Abstract Co-Author: Nothing to Disclose
Pengfei Zhao MD, Abstract Co-Author: Nothing to Disclose
Ting Li, Abstract Co-Author: Nothing to Disclose
Cheng Dong, Abstract Co-Author: Nothing to Disclose
The aim of this study is to investigate whether altered baseline brain activity presents in patients with pulsatile tinnitus using resting-state functional magnetic resonance imaging (rs-fMRI) technique.
The present study enrolled unilateral pulsatile tinnitus (PT) patients (n=42) and age-, sex-, and education matched normal control subjects (n=42) to investigate the brain structural changes, Amplitude of low-frequency fluctuation (ALFF) differences and their relationships with the clinical data between the two groups.
Compared with normal controls, structural changes were not present in patients group. PT patients showed significant increased ALFF in the bilateral precuneus, bilateral inferior frontal gyrus (IFG), and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The increased ALFF in precuneus may reflect PT awareness as well as tinnitus related distress. The abnormal ALFF in bilateral IFG may relate with PT awareness, and may reflect the changed brain functional connectivity of PT patients. The decreased ALFF in multiple occipital brain areas is considered as a downregulation adjustment of the AOAs.
The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.
The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.
Lv, H,
Wang, Z,
Yan, F,
Liu, Z,
Zhao, P,
Li, T,
Dong, C,
Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-state fMRI Study. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL.
http://archive.rsna.org/2014/14045443.html