Abstract Archives of the RSNA, 2011


SST01-01

Comparison of Breast Cancers Diagnosed in Screening Patients Aged 40-49 with and without Family History

Scientific Formal (Paper) Presentations

Presented on December 2, 2011
Presented as part of SST01: Breast Imaging (Other: Imaging Features and Use)

Participants

Stamatia V. Destounis MD, Presenter: Investigator, Siemens AG Investigator, FUJIFILM Holdings Corporation Investigator, Hologic, Inc Investigator, Koning Corporation Advisory Board, Philips Electronics NV Advisory Board, Matakina International Limited
Jenny Song MD, Abstract Co-Author: Nothing to Disclose
Posy Jane Seifert DO, Abstract Co-Author: Investigator, FUJIFILM Holdings Corporation Investigator, Koning Corporation Investigator, Hologic, Inc Consultant, Philips Electronics NV Advisory Board, Hologic, Inc
Philip F. Murphy MD, Abstract Co-Author: Investigator, FUJIFILM Holdings Corporation Investigator, Koning Corporation Investigator, Hologic, Inc
Patricia Somerville MD, Abstract Co-Author: Investigator, FUJIFILM Holdings Corporation Investigator, Koning Corporation Investigator, Hologic, Inc
Wende Logan-Young, Abstract Co-Author: Nothing to Disclose
Andrea Lynn Arieno BS, Abstract Co-Author: Nothing to Disclose
Renee Morgan RT, Abstract Co-Author: Nothing to Disclose

PURPOSE

To compare the rate of invasive disease in patients with and without family history aged 40-49.

METHOD AND MATERIALS

A retrospective review was conducted of all patients’ records to identify cancers diagnosed from 2000-2010. Pearson’s chi-square t-test was used for between-group comparisons for qualitative data. A 2-sided p-value was reported for all tests. Statistical analysis was performed in SAS-PC 9.2.

RESULTS

6,154 cancers were found in 5,813 patients during the study period; 1,071 were aged 40-49 (average 45) with 1,116 cancers (18.1%) detected. 373 patients presented for screening; 144 (39%) had family history of breast cancer (FHBC), 228 (61%) did not (NFHBC); 1 unknown. There were 16 (7.02%) NFHBC patients with personal history of breast cancer, compared to 7 (4.86%) in the FHBC group (p=0.4003). Lesions detected in NFHBC patients consisted of 86 mass, 97 calcification, 18 mass with calcium, 18 architectural distortion and 9 asymmetry. For FHBC patients; 42 mass, 69 calcification, 21 mass with calcium, 11 architectural distortion and 1 asymmetry, which was statistically significantly different from the NFHBC group (p=0.0459). 64.0% (n=146) invasive disease and 36.0% (n=82) non-invasive disease was found in the NFHBC group, and 63.2% (n=91) and 36.8% (n=53), respectively, in the FHBC group (p=0.8695). 227 of the 228 NFHBC patients and all the FHBC patients proceeded to surgery; 1 NFHBC patient did not due to metastatic disease. 67 (29.4%) NFHBC patients and 45 (31.3%) FHBC patients had positive lymph nodes (p=0.7026). 156 NFHBC patients had lumpectomy; 21 proceeded to mastectomy after initial surgery revealed residual disease/close margins. 90 lumpectomies were performed in FHBC patients; 13 had residual disease/close margins and proceeded to mastectomy. 71 (31.1%) NFHBC patients and 54 (37.5%) FHBC patients had mastectomy (p=0.2059).  

CONCLUSION

In the 40-49 group, 373 presented for screening and were diagnosed with breast cancer. Invasive cancer was diagnosed in 64% of cases presenting without family history and 63% with family history. The lymph node metastatic rate was similar at 29% without and 31% with family history. Family history does not seem to impact the rate of invasive disease in this patient cohort.

CLINICAL RELEVANCE/APPLICATION

We found women with and without family history had a significant number of cancers diagnosed, with similar rates of invasive disease and of lymph node metastases.

Cite This Abstract

Destounis, S, Song, J, Seifert, P, Murphy, P, Somerville, P, Logan-Young, W, Arieno, A, Morgan, R, Comparison of Breast Cancers Diagnosed in Screening Patients Aged 40-49 with and without Family History.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11007984.html