Ah Young Jung MD, Abstract Co-Author: Nothing to Disclose

Jung-Eun Cheon MD, Presenter: Nothing to Disclose

Tae Jin Yun, Abstract Co-Author: Nothing to Disclose

In-One Kim MD, Abstract Co-Author: Nothing to Disclose

Woo Sun Kim MD, Abstract Co-Author: Nothing to Disclose

Kyung Mo Yeon MD, Abstract Co-Author: Nothing to Disclose

To evaluate whether MR perfusion can depict the postoperative as well preoperative hemodynamic status and whether MR perfusion performed after the indirect bypass operation can predict the further clinical outcomes of moyamoya syndrome patients.

Seventy nine sets of 67 patients with MMS were studied with the use of MR perfusion with TTP and CBV as hemodynamic indicators. Data were analyzed by a quantitative regional analysis, in which the region of interest was segmented into 5 categories in preoperative and postoperative MR perfusion: ΔTTP values from over than 0 seconds, 2 seconds, 4 seconds, 6 seconds, and 8 seconds. And the postoperative clinical outcome of each patient was assigned to one of the following 4 categories on the last follow-up by their neurosurgeons: (1) excellent, (2) good, (3) fair, and (4) poor. The relationship between perfusion status and clinical outcomes was investigated.

Mean values of ΔTTP, rCBV, and number of pixels in the corresponding segmented region as a percentage of the total number of pixels in TTP perfusion maps decreased significantly after bypass surgery. Patients with higher level of Δ(ΔTTP) and more decrease in the extent of Δ(ΔTTP) after revascularization surgery in over than 0 seconds, over than 2 seconds, over than 4 seconds, and over than 6 seconds showed better clinical outcome with statistical significance.

The use of TTP and CBV perfusion maps can depict the preoperative hemodynamic status of patients with moyamoya syndrome and postoperative changes as well. We postulate that the TTP perfusion map performed after the revascularization surgery of the involved cerebral hemisphere can predict the further clinical outcomes of patients with moyamoya syndrome.

The TTP and CBV perfusion maps can demonstrate the preoperative and post operative hemodynamic status and the post operative TTP perfusion map can predict the clinical outcomes of patients with moyamoya syndrome.

Jung, A, Cheon, J, Yun, T, Kim, I, Kim, W, Yeon, K, Quantitative MR Perfusion Imaging in Moyamoya Disease: Correlation between MR Perfusion Imaging and Clinical Outcome After Revascularization Surgery.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5012808.html