Abstract Archives of the RSNA, 2007


SSG01-04

Improved Accuracy of Lesion Detection in Breast Cancer Screening with Stereoscopic Digital Mammography

Scientific Papers

Presented on November 27, 2007
Presented as part of SSG01: Breast Imaging (Digital Mammography)

Participants

David James Getty PhD, Presenter: Nothing to Disclose
Carl Joseph D'Orsi MD, Abstract Co-Author: Consultant, General Electric Company Consultant, Hologic, Inc (R2 Technology, Inc) Stock options, General Electric Company Stock options, Hologic, Inc (R2 Technology, Inc)
Ronald M. Pickett PhD, Abstract Co-Author: Nothing to Disclose
Mary S. Newell MD, Abstract Co-Author: Nothing to Disclose
Kathleen R. Gundry MD, Abstract Co-Author: Nothing to Disclose
Stephanie Felisia Roberson MD, Abstract Co-Author: Nothing to Disclose
Sandra R. Bates MD, Abstract Co-Author: Nothing to Disclose
et al, Abstract Co-Author: Nothing to Disclose
et al, Abstract Co-Author: Nothing to Disclose

PURPOSE

This is an interim report of an ongoing clinical trial of stereoscopic full-field digital mammography compared to standard (non-stereo) full-field digital mammography. Stereoscopic digital mammography permits the radiologist to view the internal structure of the breast directly and in depth. We compare the two modalities for detection of suspicious breast lesions in a screening population.

METHOD AND MATERIALS

Over 900 patients at elevated risk for the development of breast cancer have been enrolled as of March, 2007. Each patient receives both a standard screening examination and a stereoscopic screening examination which are read independently by different radiologists. If a suspicious finding is reported from either reading, the patient is recalled for standard clinical workup examinations, which form the basis for lesion truth.

RESULTS

Compared to standard digital mammography, stereo mammography is reducing false positive lesion detections by 39% (p< 0.005), and reducing false negative lesion detections by 46% (p< 0.04). ROC analysis of the readers’ paired ratings of likelihood that a finding is real show greater accuracy for stereo, Az = 0.79, than for standard, Az = 0.57 (p=0.0004).

CONCLUSION

Stereo mammography is signigicantly more accurate than standard mammography in detecting lesions in breast cancer screening,improving both sensitivity and specificity.

CLINICAL RELEVANCE/APPLICATION

Stereo mammography is significantly more accurate than standard mammography and has high promise of being both clinically acceptable and easily implemented for breast cancer screening.

Cite This Abstract

Getty, D, D'Orsi, C, Pickett, R, Newell, M, Gundry, K, Roberson, S, Bates, S, et al, , et al, , Improved Accuracy of Lesion Detection in Breast Cancer Screening with Stereoscopic Digital Mammography.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5002357.html