RSNA 2003 

Abstract Archives of the RSNA, 2003


G10-626

Uterine Artery Embolization in Sheep Using Trisacryl Microspheres and Non-Spherical PVA Particles: Comparison of Pathological Findings at 2 Years

Scientific Papers

Presented on December 2, 2003
Presented as part of G10: Vascular Interventional (Uterine Artery Embolization)

Participants

Jean-Pierre Pelage MD, PRESENTER: Nothing to Disclose

Abstract: HTML Purpose: To evaluate long-term effects of uterine artery embolization. To analyze location of the particles on pathology performed 2 years after embolization. Methods and Materials: Bilateral uterine artery embolization was performed in 20 sheep including 10 animals using non spherical PVA particles 600-1000 μ and 10 animals using trisacryl microspheres 700-900 μ(MS). Animals were sacrificed 30 months after embolization. The uterus and ovaries were removed and formalin fixation followed by HES and orcein stainings were performed. The following evaluation was performed : arterial diamater, particle size, number of particles in each vessel, particle localization (a =uterine artery branches, b=periuterine level, c=myometrium, d=endometrium). Results: No macroscopic lesion was identified. Size of occluded arteries was larger (p<.0001) with PVA (1150 ± 487, median 1140 μ) than with MS (883± 420, median 800 μ). Mean number of particles was higher (p<.0001) with PVA (13.3 ± 20.9, median 7) than with MS(2.5 ± 2.8, median 2). PVA particles were located more proximally (p<.0001) (PVA a: 70.9%, b: 21.6%, c: 6.7%, d: 0.8 %), than MS (a: 37.2 %, b: 33.2 %, c: 25.9 %, d: 3.7 %). Recanalization rates were 60 % and 65 % for MS and PVA respectively (NS, Chi2). Conclusion: No macroscopic lesion was found in embolized groups. Both embolization agents block mainly at the level of the uterine and periuterine arteries. Non spherical PVA particles tend occlude the arteries more proximally than microspheres. (J.P., A.L., received a grant and are consultants for Biosphere Medical. J.P. is also a consultant for Boston Scientific, and Biocompatibles.) Questions about this event email: jean-pierre.pelage@apr.ap-hop-paris.fr

Cite This Abstract

Pelage MD, J, Uterine Artery Embolization in Sheep Using Trisacryl Microspheres and Non-Spherical PVA Particles: Comparison of Pathological Findings at 2 Years.  Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL. http://archive.rsna.org/2003/3105977.html