Abstract Archives of the RSNA, 2003
Jean-Pierre Pelage MD, PRESENTER: Nothing to Disclose
Abstract:
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Purpose: To evaluate long-term effects of uterine artery embolization. To
analyze location of the particles on pathology performed 2 years after
embolization.
Methods and Materials: Bilateral uterine artery embolization was performed in
20 sheep including 10 animals using non spherical PVA particles 600-1000 μ
and 10 animals using trisacryl microspheres 700-900 μ(MS). Animals were
sacrificed 30 months after embolization. The uterus and ovaries were removed
and formalin fixation followed by HES and orcein stainings were performed. The
following evaluation was performed : arterial diamater, particle size, number
of particles in each vessel, particle localization (a =uterine artery branches,
b=periuterine level, c=myometrium, d=endometrium).
Results: No macroscopic lesion was identified. Size of occluded arteries was
larger (p<.0001) with PVA (1150 ±
487, median 1140 μ) than with MS (883±
420, median 800 μ). Mean number of particles was higher (p<.0001) with
PVA (13.3 ± 20.9, median 7) than with
MS(2.5 ± 2.8, median 2). PVA particles
were located more proximally (p<.0001) (PVA a: 70.9%, b: 21.6%, c: 6.7%, d:
0.8 %), than MS (a: 37.2 %, b: 33.2 %, c: 25.9 %, d: 3.7 %). Recanalization
rates were 60 % and 65 % for MS and PVA respectively (NS, Chi2).
Conclusion: No macroscopic lesion was found in embolized groups. Both
embolization agents block mainly at the level of the uterine and periuterine
arteries. Non spherical PVA particles tend occlude the arteries more proximally
than microspheres. (J.P., A.L., received a grant and are consultants for
Biosphere Medical. J.P. is also a consultant for Boston Scientific, and
Biocompatibles.)
Questions about this event email: jean-pierre.pelage@apr.ap-hop-paris.fr
Pelage MD, J,
Uterine Artery Embolization in Sheep Using Trisacryl Microspheres and Non-Spherical PVA Particles: Comparison of Pathological Findings at 2 Years. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3105977.html