Abstract:
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Purpose: To determine broadband ultrasound attenuation (BUA) and speed of sound (SOS) on the os calcis in asthmatic children comparing those suffering from atopic dermatitis to those who do not in order to evaluate effect of chronic inflammatory process of the skin and of the lung on bone density.
Methods and Materials: 64 children (31m, 34f; mean age 12.3y) suffering from asthma bronchiale and atopic dermatitis (group1) were consecutively chosen and compared to 110 children suffering from asthma exclusively (group 2). BUA and SOS were measured using SAHARA (Hologic Inc. Waltham, USA) on the calcaneal bone. Regional normative BUA and SOS data of 3299 children (obtained with the same system) were used to calculate age-, weight- and height-matched standard-deviation-scores (SDS) for both sexes. Topical steroid intake, asthma severity grade and severity and extend of atopic dermatitis using the SCORAD-score were compared, furthermore.
Results: Mean values of BUA were almost similar in both groups: +0.20 (group 1); +0.17 (group 2). Significantly different values of SOS were obtained between group 1 and 2: -0.05 and -0.40 (age related). Weight- and height-related the following values were obtained: (BUA +0.25/+0.17 and +0,26/+0.17) and SOS (-0.12/-0.08 and -0.46/-0.45) of group 1 and 2, resp. No significant correlation to SCORAD was verified for BUA: (r=-.19) and SOS (r=-.05). 9/64 and 10/110 (14%/10%) children of group 1 and 2 showed a BUA <-1SD, whereas 11/64 (17%) and 22/110 (20%) had a BUA >+1SD, resp.. 11/64 (17%) and 36/110 (33%) children of group 1 and 2 showed a SOS <-1SD, increased values were observed in 10/64 and 11/110 cases, resp. (16%/10%). Of those children ever receiving long term topical steroids 32/97 showed a SOS at least <-1SD, whereas only 15/76 showed a reduced value (33% vs. 20%). An association to asthma severity was verified. No relevant nor statistically significant sexual differences occured.
Conclusion: Further atopic diseases as atopic dermatitis do not influence speed of sound in children suffering from asthma bronchiale. The reduced values of speed of sound on asthmatic children are mainly attributed correlated to steroid application and severity of asthma but not to the degree of atopic dermatitis. Atopic dermatitis itself did not reveal any pathological findings of BUA and SOS, respectively.
Questions about this event email: ansgar.malich@med.uni-jena.de
Malich MD, A,
Influence of Severity of Atopic Dermatitis on Broadband Ultrasound Attenuation and Speed of Sound: Is There an Input of Chronic Inflammatory Process on Bone?. Radiological Society of North America 2003 Scientific Assembly and Annual Meeting, November 30 - December 5, 2003 ,Chicago IL.
http://archive.rsna.org/2003/3103657.html
